China H&Z® Benzocaine is White needle crystal, melting point of 90-92℃, slightly soluble in water, easily soluble in organic solvents. Such as: ethanol, chloroform, ether, can dissolve in almond oil, olive oil. Benzocaine, as an insoluble local anesthetic Chemicalbook, has the effect of relieving pain and itching. It is clinically used in wound anesthesia, ulcer anesthesia, mucosal surface anesthesia and hemorrhoid anesthesia. Its pharmacological effect is mainly to block nerve endings to relieve pain and itching.
China H&Z® Benzocaine Factory
Benzocaine CAS NO:94-09-7
Benzocaine Chemical Properties
MF:C9H11NO2
MW:165.19
Melting point:88-90°C
Boiling point :172°C (12.7517 mmHg)
Density :1.17
Benzocaine Specification:
Items |
Standards |
Analytical results |
||
Appearance |
Small,White crystal or powder |
white crystal powder |
||
Identification |
IR Identification |
IR should comply with the standard spectrum. |
Conform |
|
HPLC Identification |
The retention time of the major peak of the sample solution corres ponds to that of the Standard solution,as obtained in the assay. |
Conform |
||
Loss on drying |
≤0.5% |
0.01% |
||
Residue on ignition |
≤0.1% |
0.01% |
||
Chloride |
No turbidity is produced immediately. |
Conform |
||
Related substance(HPLC) |
Aminobenzoic≤0.10% |
Not detected |
||
Ethyl 4-nitrobenzoate≤0.10% |
Not detected |
|||
Any other unspecified impurity≤0.10% |
Not detected |
|||
Total impurities≤1.0% |
Not detected |
|||
Assay(HPLC) |
98.0-102.0% |
99.7% |
||
Elemental Impurities |
Pd |
≤1ppm |
0.003ppm |
|
V |
≤10ppm |
<0.00021ppm |
||
As |
≤1.5ppm |
<0.00017ppm |
||
Co |
≤5ppm |
<0.00005ppm |
||
Ni |
≤20ppm |
0.00063ppm |
||
Cd |
≤0.5ppm |
0.00002ppm |
||
Hg |
≤3ppm |
<0.00006ppm |
||
Pb |
≤0.5ppm |
<0.0003ppm |
||
Conclusion |
Conforms withUSP42. |
Benzocaine Application:
H&Z® Benzocaine is a local anesthetic, used for the pain relief of wounds, ulcers and hemorrhoids. It is also an intermediate of cough antitussive medicine.
Benzocaine, as an insoluble local anesthetic Chemicalbook, has the effect of relieving pain and itching. It is clinically used in wound anesthesia, ulcer anesthesia, mucosal surface anesthesia and hemorrhoid anesthesia. Its pharmacological effect is mainly to block nerve endings to relieve pain and itching.