Indometacin

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China H&Z® Indometacin Factory

Indometacin CAS:53-86-1

Indometacin Chemical Properties

MF:C19H16ClNO4

MW:357.79

Melting point:155-162°C

Boiling point:499.4±45.0°C(Predicted)

Density:1.2135 (rough estimate)

solubility :ethanol: 50 mg/mL, clear, yellow-green

Indometacin Specification:

TestsItems		Requirements	Results
Characters		A white pale yellow crystalline powder, Odourless or almost odourless.	Complies
Solubility		Practically insoluble in water,spaeingly soluble in wthanol(96%)	Complies
Identification	m.p.	158-162℃	158-161℃
	IR	The IR of sample which to be examined corresponding to the reference indometacin RS.	Complies
Heavy metals		≤20ppm	Complies
Loss on drying		≤0.5%	0.08%
Sulphated ash		≤0.10%	0.09%
Related substances		Single unkownn Impurity≤0.10%	0.025%
		Total Impurity≤0.3%	0.08%
Microbial limits		Aerobic bacteria per 1g must not exceed the total number of103cfu.	<10cfu
		Fungi and yeast per 1g must not exceed 102cfu	<10cfu
		Escherichia coli per 1g must not be detected	Not detected
Assay		98.0-102.0% On the dried substance	100.2%
Conclusion:The product was tested according to EP9.0,the results meet the requirements

 

Indometacin Function:

H&Z® Indometacin is anti-inflammatory, antipyretic effect is obvious, mainly used for salicylic acid drugs not easy to tolerate or curative effect is not significant rheumatic joint inflammation, ankylosing spondylitis, osteoarthritis and so on.

Indometacin Application:

The anti-inflammatory effect of indomethacin is stronger than that of butazone and hydrocortisone, and the combined application of indomethacin can reduce the dosage and side effects of the latter.

The antipyretic effect was 10 times that of aminopyrine. But the analgesic effect is weak, only has the obvious analgesic effect to the inflammatory pain.

Gastrointestinal absorption is rapid and complete after oral administration in monogastric animals. The plasma protein binding rate reached 90% at the peak of 1.5 ~ 2h. It is conjugated with glucuronic acid in the liver and excreted by the kidneys.

Some of them enter the intestines with bile and are reabsorbed, while others are discharged by feces. For postoperative trauma, arthritis, tenosynovitis, muscle injury and other inflammatory pain.