China H&Z® L-Carnosine (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues.l- Carnosine can increase the Hayflick limit in human fibroblasts,as well as appearing to reduce the telomere shortening rate. Carnosine is also considered as a geroprotector.
China L-Carnosine Factory
L-Carnosine CAS:305-84-0
L-Carnosine Chemical Properties
MF:C9H14N4O3
MW:226.23
Melting point :253°C (dec.)(lit.)
Alpha:20.9º(c=1.5, H2O)
Boiling point:367.84°C (rough estimate)
Density:1.2673 (rough estimate)
Refractive index :21°(C=2, H2O)
Water Solubility:almost transparency
L-Carnosine CAS:305-84-0 Introduction:
H&Z® L-Carnosine has been proven to scavenge reactive oxygen species (ROS) as well as alpha-beta unsaturatedaldehydes formed from peroxidation of cell membrane fatty acids during oxidative stress. Carnosine is also a zwitterion, a neutral molecule with a positive and negative end. Like carnitine, carnosine is composed of the root word carn, meaning flesh, alluding to its prevalence in animal protein. A vegetarian (especially vegan) diet is deficient in adequate carnosine, compared to levels found in a standard diet. Carnosine can increase the Hayflick limit in human fibroblasts,as well as appearing to reduce the telomere shortening rate. Carnosine is also considered as a geroprotector.
L-Carnosine CAS:305-84-0 Specification:
|
Items of analysis |
Specification |
Result |
|
Appearance |
White powder |
White powder |
|
Color |
White to almost white |
White |
|
Smell |
Odourless |
Conforms |
|
IR Spectrum |
In accordance with structure |
In accordance with structure |
|
Identification |
Must comply |
Conforms |
|
Specific Rotation[a]D20 |
+21.0±2.0o (C=2,H2O) |
+20.4°(C=2,H2O) |
|
Loss on Drying |
≤1.0% |
0.4% |
|
Melting Point |
243.0-263.0°C |
conforms |
|
Heavy Metals |
≤10ppm |
<10ppm |
|
Arsenic |
≤1ppm |
<1ppm |
|
Lead |
≤3ppm |
<3ppm |
|
Cadmium |
≤1ppm |
<1ppm |
|
Mercury |
≤0.1ppm |
<0.1ppm |
|
Residue on Ignition |
≤0.1% |
<0.05% |
|
pH(in 2% water) |
7.5~8.5 |
7.9 |
|
L-histidine |
≤1.0% |
<1.0% |
|
β-alanine |
≤0.1% |
<0.1% |
|
Total aerobes counts |
≤1000CFU/g |
<100CFU/g |
|
Mold & Yeast |
≤100CFU/g |
<10CFU/g |
|
E.Coli |
Negative |
Not Detectable |
|
Salmonella |
Negative |
Not Detectable |
|
Hydrazine content |
Not Detectable |
Not Detectable |
|
Particle Size |
100% through 100 mesh |
Conforms |
|
Loose Bulk Density |
|
0.321g/ml |
|
Assay(HPLC) |
99.0%(Area%) |
99.2% |
|
Conclusion |
Accords with the USP36 standard |
|
L-Carnosine CAS:305-84-0 Function:
1.L-Carnosine is the most effective anti-carbonylation agent yet discovered. (Carbonylation is a pathological step in the age- related degradation of the body proteins. )Carnosine helps to prevent skin collagen cross-linking which leads to loss of elasticity and wrinkles.
2 .Lcarnosine powder also acts as a regulator of zinc and copper concentrations in nerve cells, helping to prevent overstimulation by these neuroactive in the body substantiates all of the above and other studies have indicated further benefits.
3.LCarnosine is a SuperAntiOxidant that quenches even the most destructive free radicals: The hydroxyl and the peroxyl radicals, superoxide, and singlet oxygen. Carnosine helps to chelate ionic metals(flush toxins from the body).
L-Carnosine CAS:305-84-0 Application:
1.L-Carnosine protects epithelial cell membranes in the stomach and restores them to their normal metabolism
2. L-Carnosine acts as an antioxidant and protects the stomach from alcohol and smoking-induced damage.
3 L-Carnosine has anti-inflammatory properties and moderates production of interleukin-8.
4. L-Carnosine adheres to ulcerations, acts as a barrier between them and stomach acids and helps to heal them.
5. L-Carnosine inhibits activity of Helicobacter pylori bacteria;
6. L-Carnosine does not interfere with the production of prostaglandins essential to the mucosal lining of the stomach;
7. L-Carnosine strengthens these mucosal linings and stimulates production of protective mucous.
