China H&Z® L-Pyroglutamic Acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
China H&Z® L-Pyroglutamic Acid Factory
L-Pyroglutamic acid CAS:98-79-3
L-Pyroglutamic acid CAS:98-79-3 basic information:
Synonyms:5-OXO-L-PROLINE;5-oxoproline;5-OXO-2-PYRROLIDINECARBOXYLIC ACID;L-GLUTIMINIC ACID;L-GLUTAMIC ACID LACTAM;(-)-L-PYROGLUTAMIC ACID;L-PYROGLUTAMIC ACID;L-2-PYRROLIDONE-5-CARBOXYLIC ACID
MF:C5H7NO3
MW:129.11
EINECS:202-700-3
Mol File:98-79-3.mol
Appearance and Properties: White Fine Crystal
Density: 1.38 g / cm3
Melting Point: 160-163°C (lit.)
Boiling Point: 453.1ºC at 760 mmHg
Flash Point: 227.8ºC
L-Pyroglutamic acid CAS:98-79-3 Introduction
Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is a ubiquitous but little studied natural amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.
It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.
Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases. This is one of several forms of blocked N-termini which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
L-Pyroglutamic acid CAS:98-79-3 Specification:
|
Item |
Specifications |
Results |
|
Appearance |
Off-White crystalline powder |
Conforms |
|
Specific rotation(a)D20 (C=2,H20) |
-10.5°to -11.8° |
-11.6° |
|
Melting point (°C) |
158°C to 161°C |
159.5°C |
|
Chloride (C1) |
NMT 0.02% |
0.01% |
|
Ammonium (NH4) |
NMT 0.02% |
<0.02% |
|
Sulfate (SO4) |
NMT 0.05% |
0.005% |
|
Heavy metals (Pb) |
NMT 10ppm |
10ppm |
|
Iron(Fe) |
NMT 20ppm |
8ppm |
|
Arsenic (As2O3) |
NMT 1ppm |
<1ppm |
|
Loss on drying |
NMT 0.50% |
0.39% |
|
Residue on ignition |
NMT 0.2% |
0.07% |
|
Assay |
98.0-101.0% |
99.3% |
L-Pyroglutamic acid CAS:98-79-3 Function
For food, medicine, cosmetics and other industries; organic synthesis intermediates, food additives
1.L-Pyroglutamic Acid is cardio protection; prevention of atherosclerosis
2.L-Pyroglutamic Acid is cancer prevention
3.L-Pyroglutamic Acid is prevention of tooth decay and gum disease
4.L-Pyroglutamic Acid is kidney function improvement
5.L-Pyroglutamic Acid anti-platelet aggregation to prevent blood clotting
6.L-Pyroglutamic Acid is liver protection
7.L-Pyroglutamic Acid is protection and restoration of immune system
8.L-Pyroglutamic Acid is inhibition of infectious pathogens
L-Pyroglutamic acid CAS:98-79-3 Application
1. It can be used in nail cosmetics. ,
2.H&Z® L-pyroglutamic acid can also be synthesized with other organic compounds
Derivatives have special effects on surface activity, transparency and brightness. ,
3. It can be used as surfactant, detergent, chemical reagent and organic intermediate for the resolution of racemic amine.
